The aim of the study is the production of neo-skin formed by sheets of keratinocytes and / or fibroblasts treated by ex vivo gene therapy for the potential treatment of patients with epidermolysis bullosa.

The execution of this sperimentation would lead solid foundation for the treatment of a severely disabling disease from the perspective of both organic and social.

The study is divide into five main phases:

1. phase of biopsy on patients with epidermolysis bullosa, for the selection of  autologous keratinocytes / fibroblasti
2. phase of gene therapy through retroviral carrier
3. phase of amplification through keratinocytes / fibroblasti culture in vitro
4. phase of  histological analysis of the results